Autoimmunity arising from bystander proliferation of T cells in animmune response model

• Tipo: Artigo em Revista Científica Internacional
• Data: 2011

Autores

Burroughs, N.J. (Autor) FCNAUP; Ferreira, M. (Autor) Outra; Oliveira, Bruno (Autor) FCNAUP; Pinto, A.A. (Autor) FCNAUP

Revista

Título: Mathematical and Computer Modelling

Vol. 53 Nº 7/8

Páginas: 1389-1393

ISSN: 0895-7177

Editora: Pergamon Press - Elsevier

Indexação

ISI Web of Knowledge - 23 Citações

ISI Web of Science

Scopus - 26 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Ciências da saúde

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-002-SGJ

Resumo (PT): We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period. (C) 2010 Elsevier Ltd. All rights reserved.

Abstract (EN): We study a mathematical model of immune response by T cells where the regulatory T cells (Treg) inhibit interleukin 2 secretion. The bystander proliferation to an immune response is modelled. We consider an asymmetry reflecting that the difference between the growth and death rates can be higher for the active T cells and Tregs than for the inactive. This asymmetry leads to a better understanding of the bystander proliferation. An exposure to a pathogen results in an increased proliferation rate of the bystander T cells. If the population of the bystander T cells becomes large enough, autoimmunity can arise, eventually after a long transient period. (C) 2010 Elsevier Ltd. All rights reserved.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

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