MO06 - ECTS 1. Learn about the different in vivo and in vitro models of cancer research
2. How to user experimental in vivo and in vitro models of disease
3. Different methods to approach the issue of cancer research
4. Answer the questions that experimental pathology can raise when dealing with oncology issue, whatever the specialized medical field we dealing with.

MO03 - ECTS

Knowledge – at the end of the course students will be able to: Describe the main epidemiological patterns of cancer in Portugal and in the world; Identify risk factors of cancer; Describe the different types of epidemiological studies, namely observational, analytic and experimental; Explain the difference between association and causality; Internal and external validity. Describe the uses of epidemiology in planning interventions in oncology;

 

Skills - at the end of the course students will be able to: Calculate measures of frequency and measures of association; Interpret the main measures in epidemiology. Read and interpret published epidemiological studies (validity and implications for public health practice in the area of oncology);

 

Attitudes - at the end of the course students will: Be sceptical of statements based only on opinion, and demand epidemiological evidence for those statements; Advocate the importance of surveillance systems like cancer registries and the need for cooperation from health professionals in such systems.

MO07 - ECTS

The purpose of this UC is to present immune cells as a very important component of the tumor microenvironment, crucial for the efficient elimination of the tumor or, on the contrary, permissive and facilitator of tumor progression. Therefore, we will address basic concepts of innate and adaptive immunology, identifying the major immune cells and immune mediators that intervene in the context of an infection or of a tumor. We will explore the principal mechanisms by which tumor cells escape immune surveillance. The main advances in cancer therapy, namely in the area of ​​immunotherapy, will be discussed and the most recent clinical evidences will be presented.

MO04 - ECTS

By the end of the course, students should be able to:

1. Know the fundaments of descriptive statistics, probabilities and inferential statistics;
2. Apply the adequate statistical methods to the problem in hands;
3. Perform a critical evaluation of existing scientific literature;
4. Elaborate and discuss an investigation protocol.

MO01 - ECTS

To know the basic concepts of the molecular classification of the various neoplasias;

To undestand the main mechanisms of carcinogenesis and tumor progression;

To identity the mais hereditary predisposition syndromes;

To understand the concepts and to identify examples of molecular targeted therapy.

MO02 - ECTS

A total number of 18 million new diagnosis of cancer were made in 2018, the most frequent of which are lung (2.09 million cases), breast (2.09 million cases) and prostate (1.28 million cases) cancers. Cancer is the second worldwide cause of death (8.97 million deaths) after ischemic heart disease, but will likely become the first in 2060 (~18.63 million deaths). 

Advances in cancer screening, early detection, news treatments and best supportive care have contributed to increases in survival. By 2040, there will be an estimated 26 million cancer survivors, most between 60 and 80 years of age.

The purpose of this curricular unit is to enable the learner to understand the management of patients requiring oncologic care, based on current therapeutic guidelines and best practice. 

At the conclusion of this program participants will be able to:

1. Describe the biology, immunology and epidemiology of cancer;
2. Recognize the role of diet, exercise, habits and lifestyles in the etiopathogenesis of cancer;
3. Discuss screening, diagnosis and staging procedures for patients with cancer;
4. Understand the principles of surgery, systemic therapies and radiotherapy;
5. Describe appropriate modalities for managing the most common cancers and their symptoms;
6. Recognize oncologic emergencies and their initial management;
7. Address the diagnostic and therapeutic algorithm of occult primary tumors;
8. Understand the applicability in the real world of the knowledge obtained in this discipline and other of this course;
9. Briefly address the psychological, socio-economic implications of cancer, as well as the organization of cancer care institutions;
10. To value the role of clinical trials and other types of cancer research.

MO05 - ECTS

OBJECTIVES

1 - Contact with laboratory environment in the cancer problem approach

2 - Learning and compreesão of laboratorial techniques used in the areas of clinical pathology, anatomic pathology, cytogenetics and molecular biology, applicable to cancer study

3 - Recognition of the work equipment in hospital laboratories

4 - Practice work 

 

MO08 - ECTS Introduction to the field of Psycho-Oncology.

MO12 - ECTS

 1-Identify the main epigenetic mechanisms and their implications in the process of transformation and neoplastic progression

2-Understand the potential of epigenetic alterations as biomarkers for detection, assessment of prognosis and prediction of response to therapy.

3-Identify the main therapeutic strategies based on the reversibility of epigenetic changes.

MO15 - ECTS The objective of the course is to gain knowledge of the principal updated knowledge on Pharmacogenomics and Personalized Medicne. A particular focus will be given to the new biomarkers that may be in association to mechanisms of disease and to tailored therapeutic approaches. A focus will be given  Ecogenetics and Molecular Epidemiology indicating its importance to Pharmacogenomics. It is aimed to improve the student s evaluation skills to discuss the introduction of new Biomarkers as Predictive factores of the response to treament or as prognostic factors. The purpose of the course is also to prepare students to become leaders in this scientific field.

MO11 - ECTS

Develop critical skills, especially critical reading of literature in basic and clinical research in Oncology

Understanding of statistical methods and their importance to the practice of basic and clinical research in oncology.

Acquire critical skills, especially critical reading of literature in basic and clinical research in Oncology

MO10 - ECTS

1. Understand the concept of neoplasia as an alteration of growth and cell/tissue differentiation
2. Understand and apply the classification and staging system of neoplasia
3. Identify the main routine methods for the study and diagnosis of neoplasia
4. Recognize the main types of human neoplasia and their main clinical and pathological characteristics
5. Recognize the contribution of Pathology for the diagnostic and therapeutic approach of cancer patients

MO09 - ECTS

This curricular unit aims to carry out a practical internship in laboratory or clinical context.


OBJECTIVES

1-Contact laboratory / clinical environment in the cancer patient approach;

2-Learning and understanding of the technical laboratorial / clinical management methods of the main types of cancer;

3-Recognize the crucial role of the multidisciplinary diagnostic and clinical approach of cancer patients;

4-Practice Laboratory / clinical observership

MO14 - ECTS

To address the main aspects of primary, secondary, tertiary and chemo-prevention of cancer.
To evaluate the differences between the community and individual approaches to cancer prevention
To analyze the main methods of evaluation of screening, errors and determinants of the application of the screenings in the population.
To evaluate the Health Intervention Programs in the North Region as the screening of breast and cervical cancer and colorectal cancer.

MO13 - ECTS This UC is designed to prepare a research project and make its presentation. It is expected that students will be able to search the bibliography on a subject, study it and organize it in the form of an integrated update and on this they can ask questions and identify problems. They will also have to design a strategy to address these issues or problems and find solutions. All these data will be written in a synthesis document that will be supported by a presentation and an evaluation by the UC teachers.

MO16 - ECTS

This course unit aims to familiarise students with the molecular mechanisms used by cells to receive, process, amplify and integrate different signals. It will be discussed the general mechanisms, through which information is transmitted by proteins and signal transduction cascades, and the link between changes in cell signaling and cancer.

MO17 - ECTS

The student should be able to understand the relevance of xenobiotics in the etiology of cancer to humans and animals, knowing how to identify which classes / types of xenobiotics are most associated with cancer.

It should be able to identify the most common modes of exposure (occupational, environmental, accidental, iatrogenic) and the fate of xenobiotics in organisms (terrestrial and aquatic), systematizing the general mechanisms of activation and detoxification of chemical carcinogens.

They should understand strategies, namely experimental (in vitro and in vivo), for the evaluation of xenobiotics as mutagenic and / or carcinogenic agents.

They should know the pros and cons of the most commonly used model species in experimental chemical carcinogenesis.

The student should be able to, by itself and in group dynamics, present and discuss critically the focused topics, making descriptive and schematic syntheses.

MODIS02 - ECTS

Esta unidade curricular tem por objetivo a realização de um trabalho de natureza técnico-científica, de cariz inovador, no domínio científico das Ciências da Saúde. Envolve a condução de trabalhos práticos de investigação e a redação de uma dissertação, elaborada com rigor técnico-científico, que será avaliada em provas públicas no final do ano letivo. O tema, conteúdo e organização da dissertação será definido sob a supervisão do(s) orientador(es) de dissertação de Mestrado, de acordo com a legislação em vigor e as normas estabelecidas pelo Regulamento de Estudos da Universidade do Porto. Em alternativa o estudante poderá elaborar uma monografia, que será igualmente avaliada em provas públicas no final do ano letivo.

No final desta unidade curricular os estudantes deverão ter atingido os objetivos de aprendizagem descritos no artigo 15º do Decreto-Lei n.º 115/2013 de 7 de agosto de 2013.

MO19 - ECTS

Esta unidade curricular tem por objetivo a realização de um trabalho de natureza técnico-científica, de cariz inovador, no domínio científico das Ciências da Saúde. Envolve a condução de trabalhos práticos de investigação e a redação de uma dissertação, elaborada com rigor técnico-científico, que será avaliada em provas públicas no final do ano letivo. O tema, conteúdo e organização da dissertação será definido sob a supervisão do(s) orientador(es) de dissertação de Mestrado, de acordo com a legislação em vigor e as normas estabelecidas pelo Regulamento de Estudos da Universidade do Porto. Em alternativa o estudante poderá elaborar uma monografia, que será igualmente avaliada em provas públicas no final do ano letivo.

No final desta unidade curricular os estudantes deverão ter atingido os objetivos de aprendizagem descritos no artigo 15º do Decreto-Lei n.º 115/2013 de 7 de agosto de 2013.

 

MODIS01 - ECTS

Esta unidade curricular tem por objetivo a realização de um trabalho de natureza técnico-científica, de cariz inovador, no domínio científico das Ciências da Saúde. Envolve a condução de trabalhos práticos de investigação e a redação de uma dissertação, elaborada com rigor técnico-científico, que será avaliada em provas públicas no final do ano letivo. O tema, conteúdo e organização da dissertação será definido sob a supervisão do(s) orientador(es) de dissertação de Mestrado, de acordo com a legislação em vigor e as normas estabelecidas pelo Regulamento de Estudos da Universidade do Porto. Em alternativa o estudante poderá elaborar uma monografia, que será igualmente avaliada em provas públicas no final do ano letivo.

No final desta unidade curricular os estudantes deverão ter atingido os objetivos de aprendizagem descritos no artigo 15º do Decreto-Lei n.º 115/2013 de 7 de agosto de 2013.

MO18 - ECTS

Esta UC, de tipo orientação tutorial, destina-se a preparar um projecto de investigação e fazer a sua apresentação. É de esperar que os estudantes saibam pesquisar a bibliografia sobre um assunto, estudá-la e organizá-la na forma de uma actualização integrada e sobre esta saibam colocar questões e identificar problemas. Terão também de desenhar uma estratégia para abordar essas questões ou problemas e encontrar-lhes soluções. Todos estes dados serão redigidos num documento-síntese que será suporte de uma apresentação e uma avaliação por um júri qualificado.