GRIM-19 in health and disease

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2008

Autores

Valdemar Maximo (Autor) FMUP; Jorge Lima (Autor) FMUP; Paula Soares (Autor) FMUP; Andre Silva (Autor) Outra; Ines Bento (Autor) Outra; Manuel Sobrinho Simoes (Autor) FMUP

Revista

Título: Advances in Anatomic Pathology

Vol. 15 Nº 1

Páginas: 46-53

ISSN: 1072-4109

Editora: Wolters Kluwer Health

Indexação

ISI Web of Knowledge - 18 Citações

Scopus - 21 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-004-2AZ

DOI: 10.1097/pap.0b013e31815e5258

Abstract (EN): GRIM-19, a gene associated with retinoid interferon-induced mortality, was originally identified as a critical regulatory protein for interferon-P and retinoic acid-induced cell death. It was also demonstrated that GRIM-19 is involved in mitochondrial metabolism, as an integrant component of complex I of the mitochondrial respiratory chain. GRIM-19 appears, therefore, as a dual function protein involved in cell death and mitochondrial metabolism. GRIM-19 knock out leads to Complex I assembly disruption and embryonic lethality in mice, showing that it is a crucial component of the mitochondrial respiratory chain essential for early embryonic development. Recently, mutations in GRIM-19 were described in Harthle cell (mitochondrion-rich) tumors of the thyroid and down-regulation or loss of its expression were found in renal cell carcinomas, suggesting a role for GRIM- 19 in tumorigenesis. As GRIM-19 binds and inhibits the signal transducer and activator of transcription-3 (STAT3), which has been shown to be activated in several human tumors it is tempting to advance that GRIM-19 may function as a tumor suppressor gene in tumors in which STAT3 plays a major role.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8