GRIM-19 in health and disease

• Type: Another Publication in an International Scientific Journal
• Date: 2008

Authors

Valdemar Maximo (Author) FMUP; Jorge Lima (Author) FMUP; Paula Soares (Author) FMUP; Andre Silva (Author) Other; Ines Bento (Author) Other; Manuel Sobrinho Simoes (Author) FMUP

Journal

Title: Advances in Anatomic Pathology

Vol. 15 No. 1

Pages: 46-53

ISSN: 1072-4109

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 18 Citations

Scopus - 21 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-004-2AZ

DOI: 10.1097/pap.0b013e31815e5258

Abstract (EN): GRIM-19, a gene associated with retinoid interferon-induced mortality, was originally identified as a critical regulatory protein for interferon-P and retinoic acid-induced cell death. It was also demonstrated that GRIM-19 is involved in mitochondrial metabolism, as an integrant component of complex I of the mitochondrial respiratory chain. GRIM-19 appears, therefore, as a dual function protein involved in cell death and mitochondrial metabolism. GRIM-19 knock out leads to Complex I assembly disruption and embryonic lethality in mice, showing that it is a crucial component of the mitochondrial respiratory chain essential for early embryonic development. Recently, mutations in GRIM-19 were described in Harthle cell (mitochondrion-rich) tumors of the thyroid and down-regulation or loss of its expression were found in renal cell carcinomas, suggesting a role for GRIM- 19 in tumorigenesis. As GRIM-19 binds and inhibits the signal transducer and activator of transcription-3 (STAT3), which has been shown to be activated in several human tumors it is tempting to advance that GRIM-19 may function as a tumor suppressor gene in tumors in which STAT3 plays a major role.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8