Spray-drying of oil-in-water emulsions for encapsulation of retinoic acid: Polysaccharide- and protein-based microparticles characterization and controlled release studies

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Antónia Gonçalves (Autor) Outra; Berta Nogueiro Estevinho (Autor) FEUP; Fernando Rocha (Autor) FEUP

Revista

Título: Food Hydrocolloids

Vol. 124

Páginas: 1-12

ISSN: 0268-005X

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Projetos Associados

MicroDelivery - Desenvolvimento de sistemas funcionais de libertação controlada por microencapsulação de compostos ativos e naturais, com interesse terapêutico, nutricional e tecnológico

Outras Informações

ID Authenticus: P-00V-FST

DOI: 10.1016/j.foodhyd.2021.107193

Abstract (EN): Oil-in-water emulsions were proposed to produce retinoic acid (RA)-loaded biopolymer-based delivery systems applying spray-drying technology. They were characterized regarding rheological properties (i.e. viscosity), stability and droplet size distribution. The usage of a spray-dryer inlet air temperature of 130 ¿C significantly increased RA encapsulation efficiency for modified chitosan-based microparticles. Empty and oil-loaded (with and without RA) microparticles were produced with a product yield between 12 and 41%. Microparticles with a mean diameter from 1.712 ± 0.004 and 12.9 ± 0.3 ¿m were produced, as well as with a morphology that varied from a very smooth to a high rough surface structure. The time required for the complete RA release from microparticles to the surrounding environment (octanol) ¿ release time ¿ varied according to the biopolymers used in the microparticles formulations. The faster RA controlled release was registered from microparticles composed by xanthan and arabic gums (48 and 94 min, respectively). In turn, alginic acid sodium-based microparticles enabled to increase the RA release time for almost 8 h. © 2021 Elsevier Ltd

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12