Synthesis and structure-activity relationships of novel amino/nitro substituted 3-arylcoumarins as antibacterial agents

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Matos, MJ (Autor) Outra; Vazquez Rodriguez, S (Autor) Outra; Santana, L (Autor) Outra; Uriarte, E (Autor) Outra; Fuentes Edfuf, C (Autor) Outra; Santos, Y (Autor) Outra; Muñoz Crego, A (Autor) Outra

Revista

Título: Molecules

Vol. 18

Páginas: 1394-1404

ISSN: 1420-3049

Editora: MDPI

Indexação

Scopus - 43 Citações

Outras Informações

ID Authenticus: P-00R-0MX

DOI: 10.3390/molecules18021394

Abstract (EN): A new series of amino/nitro-substituted 3-arylcoumarins were synthesized and their antibacterial activity against clinical isolates of Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) was evaluated. Some of these molecules exhibited antibacterial activity against S. aureus comparable to the standards used (oxolinic acid and ampicillin). The preliminary structure-activity relationship (SAR) study showed that the antibacterial activity against S. aureus depends on the position of the 3-arylcoumarin substitution pattern. With the aim of finding the structural features for the antibacterial activity and selectivity, in the present manuscript different positions of nitro, methyl, methoxy, amino and bromo substituents on the 3-arylcoumarin scaffold were reported. © 2013 by the authors.

Idioma: Inglês

Tipo (Avaliação Docente): Científica