Synthesis and structure-activity relationships of novel amino/nitro substituted 3-arylcoumarins as antibacterial agents

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Matos, MJ (Author) Other; Vazquez Rodriguez, S (Author) Other; Santana, L (Author) Other; Uriarte, E (Author) Other; Fuentes Edfuf, C (Author) Other; Santos, Y (Author) Other; Muñoz Crego, A (Author) Other

Journal

Title: Molecules

Vol. 18

Pages: 1394-1404

ISSN: 1420-3049

Publisher: MDPI

Indexing

Scopus - 43 Citations

Other information

Authenticus ID: P-00R-0MX

DOI: 10.3390/molecules18021394

Abstract (EN): A new series of amino/nitro-substituted 3-arylcoumarins were synthesized and their antibacterial activity against clinical isolates of Staphylococcus aureus (Gram-positive) and Escherichia coli (Gram-negative) was evaluated. Some of these molecules exhibited antibacterial activity against S. aureus comparable to the standards used (oxolinic acid and ampicillin). The preliminary structure-activity relationship (SAR) study showed that the antibacterial activity against S. aureus depends on the position of the 3-arylcoumarin substitution pattern. With the aim of finding the structural features for the antibacterial activity and selectivity, in the present manuscript different positions of nitro, methyl, methoxy, amino and bromo substituents on the 3-arylcoumarin scaffold were reported. © 2013 by the authors.

Language: English

Type (Professor's evaluation): Scientific