Development of a synthetic route towards N-4,N-9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Fonte, M (Autor) Outra; Fagundes, N (Autor) Outra; Gomes, A (Autor) Outra; Ferraz, R (Autor) Outra; Prudencio, C (Autor) Outra; Maria J Araujo (Autor) FCUP; Paula Gomes (Autor) FCUP; Catia Teixeira (Autor) FCUP

Revista

Título: Tetrahedron Letters

Vol. 60

Páginas: 1166-1169

ISSN: 0040-4039

Editora: Elsevier

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 6 Citações

Outras Informações

ID Authenticus: P-00Q-ACC

DOI: 10.1016/j.tetlet.2019.03.052

Abstract (EN): A multi-step synthetic route towards N-4,N-9-disubstituted 4,9-diaminoacridines that, to the best of our knowledge, has no precedence in the literature, has been developed. The target structures are likely to reveal interesting biological activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4