Development of a synthetic route towards N-4,N-9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Fonte, M (Author) Other; Fagundes, N (Author) Other; Gomes, A (Author) Other; Ferraz, R (Author) Other; Prudencio, C (Author) Other; Maria J Araujo (Author) FCUP; Paula Gomes (Author) FCUP; Catia Teixeira (Author) FCUP

Journal

Title: Tetrahedron Letters

Vol. 60

Pages: 1166-1169

ISSN: 0040-4039

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 6 Citations

Other information

Authenticus ID: P-00Q-ACC

DOI: 10.1016/j.tetlet.2019.03.052

Abstract (EN): A multi-step synthetic route towards N-4,N-9-disubstituted 4,9-diaminoacridines that, to the best of our knowledge, has no precedence in the literature, has been developed. The target structures are likely to reveal interesting biological activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4