Cancer syndromes and therapy by stop-codon readthrough

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2012

Autores

Renata Bordeira Carrico (Autor) Outra; Ana Paula Pego (Autor) FEUP; Manuel Santos (Autor) Outra; Carla Oliveira (Autor) Outra

Revista

Título: Trends in Molecular Medicine

Vol. 18

Páginas: 667-678

ISSN: 1471-4914

Editora: Elsevier

Indexação

ISI Web of Knowledge - 15 Citações

Scopus - 18 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-002-3VM

DOI: 10.1016/j.molmed.2012.09.004

Abstract (EN): Several hereditary cancer syndromes are associated with nonsense mutations that create premature termination codons (PTC). Therapeutic strategies involving readthrough induction partially restore expression of proteins with normal function from nonsense-mutated genes, and small molecules such as aminoglycosides and PTC124 have exhibited promising results for treating patients with cystic fibrosis and Duchenne muscular dystrophy. Transgenic expression of suppressor-tRNAs and depleting translation termination factors are, among others, potential strategies for treating PTC-associated diseases. In this review, the potential of using readthrough strategies as a therapy for cancer syndromes is discussed, and we consider the effect of nonsense-mediated decay and other factors on readthrough efficiency.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12