Cancer syndromes and therapy by stop-codon readthrough

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Renata Bordeira Carrico (Author) Other; Ana Paula Pego (Author) FEUP; Manuel Santos (Author) Other; Carla Oliveira (Author) Other

Journal

Title: Trends in Molecular Medicine

Vol. 18

Pages: 667-678

ISSN: 1471-4914

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 15 Citations

Scopus - 18 Citations

Scientific classification

FOS: Medical and Health sciences > Other medical sciences

Other information

Authenticus ID: P-002-3VM

DOI: 10.1016/j.molmed.2012.09.004

Abstract (EN): Several hereditary cancer syndromes are associated with nonsense mutations that create premature termination codons (PTC). Therapeutic strategies involving readthrough induction partially restore expression of proteins with normal function from nonsense-mutated genes, and small molecules such as aminoglycosides and PTC124 have exhibited promising results for treating patients with cystic fibrosis and Duchenne muscular dystrophy. Transgenic expression of suppressor-tRNAs and depleting translation termination factors are, among others, potential strategies for treating PTC-associated diseases. In this review, the potential of using readthrough strategies as a therapy for cancer syndromes is discussed, and we consider the effect of nonsense-mediated decay and other factors on readthrough efficiency.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12