Phenolic compounds from Jacaranda caroba (Vell.) A. DC.: Approaches to neurodegenerative disorders

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Federico Ferreres (Autor) Outra; Clara Grosso (Autor) Outra; Angel Gil Izquierdo (Autor) Outra; Patricia Valentao (Autor) FFUP; Paula B Andrade (Autor) FFUP

Revista

Título: Food and Chemical Toxicology

Vol. 57

Páginas: 91-98

ISSN: 0278-6915

Editora: Elsevier

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 15 Citações

Classificação Científica

FOS: Ciências agrárias > Outras ciências agrárias

Outras Informações

ID Authenticus: P-006-9PP

DOI: 10.1016/j.fct.2013.03.012

Abstract (EN): Diseases affecting the central nervous system are spread throughout the world. As so, more efficient and safe neuroprotective drugs are required. The present study describes, for the first time, the phenolic composition and bioactivity of Jacaranda caroba (Vell.) A. DC, a species whose infusion is consumed as traditional medicine. The HPLC-DAD-ESI/MSn analysis revealed the presence of four dicaffeoyl acid derivatives and nine flavonoids, comprising quercetin, kaempferol and isorhamnetin derivatives. Twelve compounds are described for the first time in Jacaranda genus. Although isorhamnetin-3-O-rhmanoside-7,4'-di-O-glucoside and quercetin-3-O-(2-pentosyl)hexoside are the main metabolites in both aqueous and hydromethanolic extracts, qualitative and quantitative differences were found between them. Aqueous extract is richer in dicaffeoyl acid derivatives. Both extracts proved to be strong radicals' scavengers and effective monoamine-oxidase A inhibitors, but showed weak protection against cholinesterases' activity. The results highlight the value off. caroba as a source of health-promoting antioxidants and antidepressant compounds.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8