Phenolic compounds from Jacaranda caroba (Vell.) A. DC.: Approaches to neurodegenerative disorders

• Type: Article in International Scientific Journal
• Date: 2013

Authors

Federico Ferreres (Author) Other; Clara Grosso (Author) Other; Angel Gil Izquierdo (Author) Other; Patricia Valentao (Author) FFUP; Paula B Andrade (Author) FFUP

Journal

Title: Food and Chemical Toxicology

Vol. 57

Pages: 91-98

ISSN: 0278-6915

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 15 Citations

Scientific classification

FOS: Agrarian Sciences > Other Agrarian Sciences

Other information

Authenticus ID: P-006-9PP

DOI: 10.1016/j.fct.2013.03.012

Abstract (EN): Diseases affecting the central nervous system are spread throughout the world. As so, more efficient and safe neuroprotective drugs are required. The present study describes, for the first time, the phenolic composition and bioactivity of Jacaranda caroba (Vell.) A. DC, a species whose infusion is consumed as traditional medicine. The HPLC-DAD-ESI/MSn analysis revealed the presence of four dicaffeoyl acid derivatives and nine flavonoids, comprising quercetin, kaempferol and isorhamnetin derivatives. Twelve compounds are described for the first time in Jacaranda genus. Although isorhamnetin-3-O-rhmanoside-7,4'-di-O-glucoside and quercetin-3-O-(2-pentosyl)hexoside are the main metabolites in both aqueous and hydromethanolic extracts, qualitative and quantitative differences were found between them. Aqueous extract is richer in dicaffeoyl acid derivatives. Both extracts proved to be strong radicals' scavengers and effective monoamine-oxidase A inhibitors, but showed weak protection against cholinesterases' activity. The results highlight the value off. caroba as a source of health-promoting antioxidants and antidepressant compounds.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8