Functionalized gold nanoparticles for drug delivery

• Tipo: Artigo em Livro de Atas de Conferência Internacional
• Data: 2013

Autores

Sandra Rocha (Autor) Outra; Maria do Carmo Pereira (Autor) FEUP; Manuel A. N. Coelho (Autor) FEUP; Sílvia Castro Coelho (Autor) FEUP; Petras Juzenas (Autor) Outra

Ata de Conferência Internacional

Título: 3rd Portuguese Bioengineering Meeting, ENBENG 2013 - Book of Proceedings

Páginas: 1-4

3rd Portuguese Bioengineering Meeting

Braga, PORTUGAL, FEB 20-23, 2013

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

INSPEC

Classificação Científica

FOS: Ciências da engenharia e tecnologias > Biotecnologia ambiental

Projetos Associados

BIONANO - Distibuição de biomoleculas através de nanopartículas inorganica/organicas

Outras Informações

ID Authenticus: P-006-FH5

DOI: 10.1109/enbeng.2013.6518389

Abstract (EN): Gold nanoparticles are versatile vectors for biological applications including in cancer therapy and diagnosis. Combining gold nanoparticles/anticancer drugs with X-rays radiation may contribute to tumor eradication and treatment efficacy. The conjugation of a proteasome inhibitor (BTZ) with functionalized gold nanoparticles were tested. The drug activity and the anticancer effects in human prostate cancer cells (Du-145) were evaluated. It was observed that gold nanoparticles, with small diameters (24 nm), at concentrations of 0.1 nM are not toxic for Du-145 cells. Finally, nanoparticle parameters were discussed and new ideas are proposed to optimize the anticancer properties of conjugated gold nanoparticles leading to a better delivery of the drug, minimizing the side effects.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4