Functionalized gold nanoparticles for drug delivery

• Type: Article in International Conference Proceedings Book
• Date: 2013

Authors

Sandra Rocha (Author) Other; Maria do Carmo Pereira (Author) FEUP; Manuel A. N. Coelho (Author) FEUP; Sílvia Castro Coelho (Author) FEUP; Petras Juzenas (Author) Other

Conference proceedings International

Title: 3rd Portuguese Bioengineering Meeting, ENBENG 2013 - Book of Proceedings

Pages: 1-4

3rd Portuguese Bioengineering Meeting

Braga, PORTUGAL, FEB 20-23, 2013

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

INSPEC

Scientific classification

FOS: Engineering and technology > Environmental biotechnology

Associated Projects

BIONANO - Distibuição de biomoleculas através de nanopartículas inorganica/organicas

Other information

Authenticus ID: P-006-FH5

DOI: 10.1109/enbeng.2013.6518389

Abstract (EN): Gold nanoparticles are versatile vectors for biological applications including in cancer therapy and diagnosis. Combining gold nanoparticles/anticancer drugs with X-rays radiation may contribute to tumor eradication and treatment efficacy. The conjugation of a proteasome inhibitor (BTZ) with functionalized gold nanoparticles were tested. The drug activity and the anticancer effects in human prostate cancer cells (Du-145) were evaluated. It was observed that gold nanoparticles, with small diameters (24 nm), at concentrations of 0.1 nM are not toxic for Du-145 cells. Finally, nanoparticle parameters were discussed and new ideas are proposed to optimize the anticancer properties of conjugated gold nanoparticles leading to a better delivery of the drug, minimizing the side effects.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4