Sensibility of the quorum growth thresholds controlling local immune responses Q

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

N. J. Burroughs (Autor) Outra; B. M. P. M. Oliveira (Autor) Outra; A. A. Pinto (Autor) FCUP; H. J. T. Sequeira, (Autor) Outra

Revista

Título: Mathematical and Computer Modelling

Vol. 47

Páginas: 714-725

ISSN: 0895-7177

Editora: Pergamon Press - Elsevier

Classificação Científica

CORDIS: Ciências Físicas > Matemática

FOS: Ciências exactas e naturais > Matemática

Outras Informações

Resumo (PT): The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs.

Abstract (EN): The consequences of regulatory T cell (Treg) inhibition of interleukine 2 secretion are examined by mathematical modelling. We demonstrate that cytokine dependent growth exhibits quorum T cell population thresholds that determine whether immune responses develop on activation and whether the immune system returns to a control state. We study the effects in the quorum T cell population thresholds, by the T cell maximum growth rate, by the growth rate ratio between Tregs and T cells, by the value of the secretion rate of cytokines, and by the effectiveness of T cell secretion inhibition by Tregs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Notas: Q