Sporadic ret-rearranged papillary carcinoma of the thyroid: A subset of slow growing, less aggressive thyroid neoplasms?

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

Soares, P (Autor) Outra; Fonseca, E (Autor) Outra; Wynford Thomas, D (Autor) Outra; Sobrinho Simoes, M (Autor) FMUP

Revista

Título: Journal of Pathology

Vol. 185

Páginas: 71-78

ISSN: 0022-3417

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 104 Citações

Scopus - 117 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-001-81C

DOI: 10.1002/(sici)1096-9896(199805)185:1<71::aid-path42>3.0.co;2-s

Abstract (EN): Despite the large amount of information accumulated on the role played by vet activation in the oncogenesis of papillary thyroid carcinoma (PTC), the biological and clinical significance of such activation 'in vivo' remains controversial. The aim of this study was to address some of the existing controversies by comparing two groups of unselected PTCs, one with and the other without ret rearrangement, with regard to several clinicopathological and biological features. Thirty-three PTCs mere selected at random, vet rearrangement was found in eight cases (24.2 per cent) using Southern blot analysis. The mean age of the patients with tumours displaying ret rearrangement (28 +/- 3.1 years) was significantly lower than that of the patients harbouring cases that did not present rearrangement (45 +/- 2.9 years). The large majority of the tumours with ret rearrangement displayed a papillary or mixed follicular-papillary pattern and very low proliferative activity. ret rearrangement correlated significantly with decreased cytoplasmic expression of E-cadherin. No significant differences were found regarding the gender of the patients, tumour size, multicentricity, extrathyroidal growth, vascular invasion, lymphocytic infiltration, lymph node involvement or the expression of E-cadherin (membrane), c-erb-B2, c-met, Bcl-2, and vimentin. It is proposed that sporadic PTCs harbouring a ret rearrangement occur frequently as slow growing, papillary, or predominantly papillary tumours that do not usually progress towards less differentiated neoplasms representing what might be described as a Bonsai phenotype. (C) 1998 John Wiley & Sons, Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8