T-CELL REGULATION OF THE CHRONIC PERITONEAL NEUTROPHILIA DURING MYCOBACTERIAL INFECTIONS

• Tipo: Artigo em Revista Científica Internacional
• Data: 1992

Autores

APPELBERG, R (Autor) ICBAS

Revista

Título: Clinical and Experimental Immunology

Vol. 89

Páginas: 120-125

ISSN: 0009-9104

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 18 Citações

Scopus - 13 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-PDA

Abstract (EN): Intraperitoneal infection of mice with mycobacteria induces the persistent mobilization of neutrophils to the infected peritoneal cavities. The recruitment of the neutrophils was mediated by the immune system since it was enhanced by immunization and reduced in T cell-deficient nude and SCID mice. Anti-mitotic treatments with cyclophosphamide or X-rays led to a reduction in the number of mononuclear cells in the peritoneal cavity of infected mice, followed by a reduction in neutrophil numbers despite the presence of a normal circulating pool of neutrophils. The depletion of T cells with antibodies during mycobacterial i.p. infection led to a reduction in the number of neutrophils. Such a reduction was more extensive if the antibodies were administered early. Our data suggest that T cells are partially involved in the direct recruitment of neutrophils during chronic mycobacteriosis but they also play a role in the priming of other cell types for the mobilization of these phagocytes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6