NEUTROPHILS AS EFFECTOR-CELLS OF T-CELL-MEDIATED, ACQUIRED-IMMUNITY IN MURINE LISTERIOSIS

• Tipo: Artigo em Revista Científica Internacional
• Data: 1994

Autores

APPELBERG, R (Autor) ICBAS; CASTRO, AG (Autor) Outra; SILVA, MT (Autor) Outra

Revista

Título: Immunology

Vol. 83

Páginas: 302-307

ISSN: 0019-2805

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 42 Citações

Scopus - 44 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-JH3

Abstract (EN): The control of the infections caused by Listeria monocytogenes, considered an example of an intracellular parasite, is thought to involve co-operation between antigen-specific T cells and activated macrophages. Here we investigated the participation of polymorphonuclear leucocytes in the mechanisms of resistance during the immune phase of the antimicrobial response to L. monocytogenes infection. We found that BALB/c mice were unable to express T-cell-mediated (acquired) immunity to this pathogen in the absence of granulocytes. We propose that neutrophils should be included in the concept of cell-mediated immunity and that their antimicrobial role is not exclusively expressed during the early phases of a primary infection.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6