The network of P-glycoprotein and microRNAs interactions

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2014

Autores

Vanessa Lopes Rodrigues (Autor) Outra; Hugo Seca (Autor) Outra; Diana Sousa (Autor) Outra; Emilia Sousa (Autor) FFUP; Raquel T Lima (Autor) Outra; Helena Vasconcelos, MH (Autor) FFUP

Revista

Título: International Journal of Cancer

Vol. 135

Páginas: 253-263

ISSN: 0020-7136

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 47 Citações

Scopus - 52 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-008-PKB

DOI: 10.1002/ijc.28500

Abstract (EN): Overexpression of P-glycoprotein (P-gp) contributes to the multidrug resistance (MDR) phenotype found in many cancer cells. P-gp has been identified as a promising molecular target, although attempts to find successful therapies to counteract its function as a drug efflux pump have largely failed to date. Apart from its role in drug efflux, P-gp may have other cellular functions such as being involved in apoptosis, and is found in various locations in the cell. Its expression is highly regulated, namely by microRNAs (miRNAs or miRs). In addition, P-gp may regulate the expression of miRs in the cell. Furthermore, both P-gp and miRs may be found in microvesicles or exosomes and may be transported to neighboring, drug-sensitive cells. Here, we review this current issue together with recent evidence of this network of interactions between P-gp and miRs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11