Xanthones as inhibitors of growth of human cancer cell lines and their effects on the proliferation of human lymphocytes in vitro

• Tipo: Artigo em Revista Científica Internacional
• Data: 2002

Autores

Pedro, M (Autor) Outra; Cerqueira, F (Autor) Outra; Sousa, ME (Autor) Outra; Nascimento, MSJ (Autor) FFUP; Pinto, M (Autor) FFUP

Revista

Título: Bioorganic and Medicinal Chemistry

Vol. 10

Páginas: 3725-3730

ISSN: 0968-0896

Editora: Elsevier

Indexação

ISI Proceedings

ISI Web of Knowledge - 126 Citações

Scopus - 133 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-000-M4Y

DOI: 10.1016/s0968-0896(02)00379-6

Abstract (EN): Twenty-seven oxygenated xanthones have been assessed for their capacity to inhibit in vitro the growth of three human cancer cell lines, MCF-7 (breast cancer). TK-10 (renal cancer) and UACC-62 (melanoma). The effect of these xanthones on the proliferation of human T-lymphocytes was also evaluated. Differences on their potency towards the effect on the growth of the human cancer cell lines as well as on the proliferation of human T-lymphocytes can be ascribed to the nature and positions of the substituents on the xanthonic nucleus.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6