Ribonucleotide Reductase: A Mechanistic Portrait of Substrate Analogues Inhibitors

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2010

Autores

Perez, MAS (Autor) Outra; Cerqueira, NMFSA (Autor) FCUP; Fernandes, PA (Autor) FCUP; Ramos, MJ (Autor) FCUP

Revista

Título: Current Medicinal Chemistry

Vol. 17 Nº 26

Páginas: 2854-2872

ISSN: 0929-8673

Editora: Bentham

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 13 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-003-378

DOI: 10.2174/092986710792065054

Abstract (EN): Ribonucleotide reductase (RNR) is the key enzyme in the biosynthesis of deoxyribonucleotides. Several different strategies for inactivation of RNRs have been reported, including the use of substrate analogues as mechanism-based inhibitors. This article undergoes a critical analysis on the current status of ribonucleotide reductase inhibitory mechanisms by substrate analogues highlighting experimental and theoretical/computational approaches. We have summarized a general portrait of the inhibitory mechanisms and classified the nucleoside analogue inhibitors in three main classes. The critical analysis undertaken will contribute in finding new and more effective ways of inhibiting RNR.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 19