Vessel density assessed by endoglin expression in breast carcinomas with different expression profiles

• Tipo: Artigo em Revista Científica Internacional
• Data: 2009

Autores

Schmitt F (Autor) FMUP

Revista

Título: Histopathology

Vol. 55 Nº 4

Páginas: 594-599

ISSN: 0309-0167

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 15 Citações

Scopus - 17 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Outras ciências médicas

Outras Informações

ID Authenticus: P-003-EN4

DOI: 10.1111/j.1365-2559.2009.03417.x

Abstract (EN): Vessel density assessed by endoglin expression in breast carcinomas with different expression profiles Aims: To evaluate the relationship between microvessel density assessed by endoglin expression and the molecular subtypes of human invasive breast carcinomas and whether there is evidence to indicate that angiogenesis could be a putative target for therapy in specific subsets of breast cancer. Methods and results: We studied a series of 161 breast carcinomas, but information was available on only 142 tumours. We correlated endoglin expression with distinct breast carcinoma subgroups classified according to immunohistochemical profiling. Additionally, we compared it with other biomarkers for the aggressive basal-like subset and with available histopathological data. Although the basal-like subtype has higher microvessel density, there are no significant differences with the other molecular subtypes of breast cancer. Conclusions: This study found no significant differences in tumour vascularity in different molecular subtypes of breast cancer.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6