RET/PTC rearrangement is prevalent in follicular Hurthle cell carcinomas

• Tipo: Artigo em Revista Científica Internacional
• Data: 2012

Autores

Margriet M de Vries (Autor) Outra; Ricardo Celestino (Autor) Outra; Patricia Castro (Autor) FMUP; Catarina Eloy (Autor) FMDUP; Valdemar Maximo (Autor) FMUP; Jacqueline E van der Wal (Autor) Outra; John T M Plukker (Autor) Outra; Thera P Links (Autor) Outra; Robert M W Hofstra (Autor) Outra; Manuel Sobrinho Simoes (Autor) FMUP; Paula Soares (Autor) FMUP

Revista

Título: Histopathology

Vol. 61

Páginas: 833-843

ISSN: 0309-0167

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 35 Citações

ISI Web of Science

Scopus - 46 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-002-42G

DOI: 10.1111/j.1365-2559.2012.04276.x

Abstract (EN): Aims: The molecular alterations underlying follicular Hurthle cell carcinomas (FHCCs) are largely unknown. In an attempt to clarify this issue, we analysed a series of Hurthle cell tumours for the presence of RET/PTC and PAX8/PPARG rearrangements and BRAF, HRAS and NRAS mutations. Methods and results: We investigated a series of 20 follicular Hurthle cell tumours [17 FHCCs and three follicular Hurthle cell adenomas (FHCAs)]. RET/PTC rearrangements were found in 33% of FHCAs and in 38% of FHCCs. All RET/PTC-positive FHCCs had a solid pattern of growth. PAX8/PPARG rearrangement was present in 27% of the FHCCs which displayed, in most cases, a follicular architecture. NRAS mutation was detected in one FHCC. An FHCC with a solid/microfollicular growth pattern scored positive for both RET/PTC and PAX8/PPARG rearrangement. Conclusions: Our study has shown a significant association between RET/PTC rearrangements and FHCCs with a solid growth pattern, thus raising the possibility of using tyrosine kinase inhibitors for the treatment of patients with FHCCs, which are often refractory to radioiodine treatment.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11