Diazepam Fluorimetric Monitoring Upon Photo-Degradation in an Automatic Miniaturized Flow System

• Tipo: Artigo em Revista Científica Internacional
• Data: 2010

Autores

David S M Ribeiro (Autor) Outra; Joao A V Prior (Autor) FFUP; Joao L M Santos (Autor) FFUP; Jose L F C Lima (Autor) FFUP

Revista

Título: Journal of Fluorescence

Vol. 20

Páginas: 915-922

ISSN: 1053-0509

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 4 Citações

ISI Web of Science

Scopus - 4 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-003-5AX

DOI: 10.1007/s10895-010-0637-x

Resumo (PT): The present work describes the fully integration in line of a photo-degradation unit, comprising a low pressure UV lamp, in a Multipumping Flow System (MPFS), for the fluorimetric chemical control of commercially available pharmaceutical formulations containing diazepam. The utilization of an organized micellar medium provided enhanced fluorescence emission. The results allowed to obtain a linear working range for diazepam concentrations of up to 40 mg L−1 (r = 0.9998) and the detection limit was about 0.97 mg L−1. The results obtained by the miniaturized and automatic flow system were in agreement with those furnished by the reference procedure, with relative deviations comprised between −2.09% and 2.13%. <br> <br> Keywords Miniaturized - Flow analysis - Multipumping - Diazepam - Photo-degradation - Spectrofluorimetry <br> <a target="_blank" href="http://www.springerlink.com/content/6513748p236m1u26/"> Texto integral <br> <br>

Abstract (EN): The present work describes the fully integration in line of a photo-degradation unit, comprising a low pressure UV lamp, in a Multipumping Flow System (MPFS), for the fluorimetric chemical control of commercially available pharmaceutical formulations containing diazepam. The utilization of an organized micellar medium provided enhanced fluorescence emission. The results allowed to obtain a linear working range for diazepam concentrations of up to 40 mg L(-1) (r = 0.9998) and the detection limit was about 0.97 mg L(-1). The results obtained by the miniaturized and automatic flow system were in agreement with those furnished by the reference procedure, with relative deviations comprised between -2.09% and 2.13%.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8