Propargylamine: an important moiety in drug discovery

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2023

Autores

Carneiro, A (Autor) Outra; Uriarte, E (Autor) Outra; Fernanda Borges (Autor) FCUP; Matos, MJ (Autor) FCUP

Revista

Título: Future Medicinal Chemistry

Vol. 15

Páginas: 211-224

ISSN: 1756-8919

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 3 Citações

Scopus

Outras Informações

ID Authenticus: P-00Y-43C

DOI: 10.4155/fmc-2022-0243

Abstract (EN): Propargylamine is a chemical moiety whose properties have made it a widely distributed group within the fields of medicinal chemistry and chemical biology. Its particular reactivity has traditionally popularized the preparation of propargylamine derivatives using a large variety of synthetic strategies, which have facilitated the access to these compounds for the study of their biomedical potential. This review comprehensively covers and analyzes the applications that propargylamine-based derivatives have achieved in the drug discovery field, both from a medicinal chemistry perspective and from a chemical biology-oriented approach. The principal therapeutic fields where propargylamine-based compounds have made an impact are identified, and a discussion of their influence and growing potential is included. Tweetable abstractPropargylamine derivatives are commonly present in various areas of #drugdiscovery. In this new @fsgfmc review article, scientists @aitorcarneiro and @mariacmatos from @UPorto and @UniversidadeUSC discuss the reasons underlying recent uses and applications of these compounds.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 14