The Role of Neutrophils in Biomaterial-Based Tissue Repair-Shifting Paradigms

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2023

Autores

Sousa, AB (Autor) Outra; Judite N Barbosa (Autor) ICBAS

Revista

Título: JOURNAL OF FUNCTIONAL BIOMATERIALS

Vol. 14 Nº 5

Página Final: 327

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Y-KNK

DOI: 10.3390/jfb14060327

Abstract (EN): Tissue engineering and regenerative medicine are pursuing clinical valid solutions to repair and restore function of damaged tissues or organs. This can be achieved in different ways, either by promoting endogenous tissue repair or by using biomaterials or medical devices to replace damaged tissues. The understanding of the interactions of the immune system with biomaterials and how immune cells participate in the process of wound healing are critical for the development of successful solutions. Until recently, it was thought that neutrophils participate only in the initial steps of an acute inflammatory response with the role of eliminating pathogenic agents. However, the appreciation that upon activation the longevity of neutrophils is highly increased and the fact that neutrophils are highly plastic cells and can polarize into different phenotypes led to the discovery of new and important actions of neutrophils. In this review, we focus on the roles of neutrophils in the resolution of the inflammatory response, in biomaterial-tissue integration and in the subsequent tissue repair/regeneration. We also discuss the potential of neutrophils for biomaterial-based immunomodulation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12