Immunomodulatory biomaterial-based wound dressings advance the healing of chronic wounds via regulating macrophage behavior

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2022

Autores

Sousa, AB (Autor) Outra; Aguas, AP (Autor) Outra; Barbosa, MA (Autor) Outra; Judite N Barbosa (Autor) ICBAS

Revista

Título: Regenerative Biomaterials

Vol. 9

ISSN: 2056-3418

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 0 Citações

Scopus

Outras Informações

ID Authenticus: P-00X-CGM

DOI: 10.1093/rb/rbac065

Abstract (EN): Successful wound healing is a process that has three overlying phases: inflammatory, proliferative and remodeling. Chronic wounds are characterized by a perpetuated inflammation that inhibits the proliferative and remodeling phases and impairs the wound healing. Macrophages are key modulators of the wound healing process. Initially, they are responsible for the wound cleaning and for the phagocytosis of pathogens and afterwards they lead to the resolution of the inflammatory response and they express growth factors important for angiogenesis and cytokines and growth factors needed for cell proliferation and deposition of extracellular matrix. The phenotype of the macrophage changes gradually throughout the healing process from the initial M1 pro-inflammatory phenotype characteristic of the acute response to the M2 pro-regenerative phenotype that allows an accurate tissue repair. In chronic wounds, M1 pro-inflammatory macrophages persist and impair tissue repair. As such, immunomodulatory biomaterials arise as promising solutions to accelerate the wound healing process. In this review, we discuss the importance of macrophages and their polarization throughout the different phases of wound healing; macrophage dysfunction in chronic wounds and the use of immunomodulatory biomaterials to overcome the critical problem of chronic wounds-the continued inflammatory phase that impairs healing.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12