CHROMOSOME-ABNORMALITIES IN BENIGN HYPERPROLIFERATIVE DISORDERS OF EPITHELIAL AND STROMAL BREAST-TISSUE

• Tipo: Artigo em Revista Científica Internacional
• Data: 1995

Autores

DIETRICH, CU (Autor) Outra; PANDIS, N (Autor) Outra; Manuel R Teixeira (Autor) Outra; BARDI, G (Autor) Outra; GERDES, AM (Autor) Outra; ANDERSEN, JA (Autor) Outra; HEIM, S (Autor) Outra

Revista

Título: International Journal of Cancer

Vol. 60

Páginas: 49-53

ISSN: 0020-7136

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 82 Citações

Scopus - 83 Citações

Outras Informações

ID Authenticus: P-008-QA9

DOI: 10.1002/ijc.2910600107

Abstract (EN): Cytogenetic analysis of short-term cultures from 15 cases of benign proliferative breast disease (PBD), 1O diffuse PBD and 5 papillomas, and 15 fibroadenomas of the breast revealed clonal chromosome abnormalities in 7 diffuse PBD lesions, 4 papillomas and 5 fibroadenomas. The remaining 14 cases had a normal female chromosome complement. Cytogenetically unrelated abnormal clones were seen in 4 fibroadenomas and 2 PBDs. A single abnormal clone was found in 9 PBDs and 1 fibroadenoma. Three clonal abnormalities were seen as recurrent changes in 6 cases, namely interstitial deletions of 3p with 3p12-14 as the minimally common deleted segment (in 1 papilloma, 1 diffuse PBD with atypia and 1 mixed-pattern lesion with both papilloma and atypical diffuse PBD features), r(9)(p24q34) (in 1 diffuse PBD and 1 fibroadenoma), and del(1)(q12) (again in 1 diffuse PBD and 1 fibroadenoma). Intriguingly, 6 of the 16 abnormal cases had chromosome changes that have been seen repeatedly as primary abnormalities in breast carcinomas: der(16)t(1;16)(q10;p10), del(3)(p12p14), and del(1)(q12). We conclude that some of the chromosome anomalies frequently found in breast carcinomas are also present in PBD and fibroadenomas. These aberrations may be accepted as early, neoplasia-relevant mutations. However, they do not seem to be sufficient by themselves to unleash a malignant process. (C) 1995 Wiley-Liss, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5