Cytogenetic comparison of primary tumors and lymph node metastases in breast cancer patients

• Tipo: Artigo em Revista Científica Internacional
• Data: 1998

Autores

Pandis, N (Autor) Outra; Manuel R Teixeira (Autor) Outra; Adeyinka, A (Autor) Outra; Rizou, H (Autor) Outra; Bardi, G (Autor) Outra; Mertens, F (Autor) Outra; Andersen, JA (Autor) Outra; Bondeson, L (Autor) Outra; Sfikas, K (Autor) Outra; Qvist, H (Autor) Outra; Apostolikas, N (Autor) Outra; Mitelman, F (Autor) Outra; Heim, S (Autor) Outra

Revista

Título: Genes Chromosomes and Cancer

Vol. 22

Páginas: 122-129

ISSN: 1045-2257

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 49 Citações

Scopus - 49 Citações

Outras Informações

ID Authenticus: P-008-QA0

DOI: 10.1002/(sici)1098-2264(199806)22:2<122::aid-gcc6>3.0.co;2-z

Abstract (EN): Chromosome banding analysis of primary tumors and axillary lymph node metastases from IO breast cancer patients revealed abnormal karyotypes in all samples with cytogenetic similarities between the primary tumor and the metastasis in all informative pairs. Although karyotypically unrelated clones were also bound in the lymph node samples, they were less numerous than in the primary tumors, indicating that there was more genetic heterogeneity among the neoplastic cells in the primary than in the secondary tumors. On the other hand, some of the clones had become more complex in the metastases as a result of clonal evolution, and by and large these metastatic breast cancer cases had more karyotypic anomalies than do unselected primary breast carcinomas. Among the aberrations occurring more frequently, and that consequently may predispose to disease spread, were losses of chromosomes 17 and 22 and homogeneously staining regions, a cytogenetic sign of gene amplification. (C) 1998 Wiley-Liss, Inc.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8