Multiple numerical chromosome aberrations in cancer: what are their causes and what are their consequences?

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2005

Autores

Manuel R Teixeira (Autor) ICBAS; Heim, S (Autor) Outra

Revista

Título: Seminars in Cancer Biology

Vol. 15

Páginas: 3-12

ISSN: 1044-579X

Editora: Elsevier

Indexação

ISI Web of Knowledge - 33 Citações

Scopus - 35 Citações

Outras Informações

ID Authenticus: P-000-4Z6

DOI: 10.1016/j.semcancer.2004.09.006

Abstract (EN): Several neoplastic tumor types are cytogenetically characterized by multiple numerical chromosome abnormalities without concomitant structural karyotypic changes. At present, no good gene-level theories are at hand to explain the pathogenetic effect of these changes during tumorigenesis. nor is it known how they arise or what causes them. Genetic instability is often invoked as an underlying cause. but actual data favoring this explanation are meager or non-existing. Numerical chromosome changes and ploidy shifts allow the simultaneous alteration of multiple cancer-relevant genes, thereby reducing the number of independent genomic events necessary for carcinogenesis and the need for postulating genomic instability as a necessity in cancer development.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10