Yoghurt Intake and Gastric Cancer: A Pooled Analysis of 16 Studies of the StoP Consortium

• Tipo: Artigo em Revista Científica Internacional
• Data: 2023

Autores

Collatuzzo, G (Autor) Outra; Negri, E (Autor) Outra; Pelucchi, C (Autor) Outra; Bonzi, R (Autor) Outra; Turati, F (Autor) Outra; Rabkin, CS (Autor) Outra; Liao, LM (Autor) Outra; Sinha, R (Autor) Outra; Palli, D (Autor) Outra; Ferraroni, M (Autor) Outra; Lopez Carrillo, L (Autor) Outra; Lunet N (Autor) FMUP; Morais, S (Autor) Outra; Albanes, D (Autor) Outra; Weinstein, SJ (Autor) Outra; Parisi, D (Autor) Outra; Zaridze, D (Autor) Outra; Maximovitch, D (Autor) Outra; Dierssen Sotos, T (Autor) Outra; Jimenez Moleon, JJ (Autor) Outra; Vioque, J (Autor) Outra; de la Hera, MG (Autor) Outra; Curado, MP (Autor) Outra; Dias Neto, E (Autor) Outra; Hernandez Ramirez, RU (Autor) Outra; Lopez Cervantes, M (Autor) Outra; Ward, MH (Autor) Outra; Tsugane, S (Autor) Outra; Hidaka, A (Autor) Outra; Lagiou, A (Autor) Outra; Lagiou, P (Autor) Outra; Zhang, ZF (Autor) Outra; Trichopoulou, A (Autor) Outra; Karakatsani, A (Autor) Outra; Camargo, MC (Autor) Outra; La Vecchia, C (Autor) Outra; Boffetta, P (Autor) Outra

Revista

Título: Nutrients

Página Final: 1877

ISSN: 2072-6643

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00Y-8RR

DOI: 10.3390/nu15081877

Abstract (EN): Background: Yoghurt can modify gastrointestinal disease risk, possibly acting on gut microbiota. Our study aimed at exploring the under-investigated association between yoghurt and gastric cancer (GC). Methods: We pooled data from 16 studies from the Stomach Cancer Pooling (StoP) Project. Total yoghurt intake was derived from food frequency questionnaires. We calculated study-specific odds ratios (ORs) of GC and the corresponding 95% confidence intervals (CIs) for increasing categories of yoghurt consumption using univariate and multivariable unconditional logistic regression models. A two-stage analysis, with a meta-analysis of the pooled adjusted data, was conducted. Results: The analysis included 6278 GC cases and 14,181 controls, including 1179 cardia and 3463 non-cardia, 1191 diffuse and 1717 intestinal cases. The overall meta-analysis revealed no association between increasing portions of yoghurt intake (continuous) and GC (OR = 0.98, 95% CI = 0.94-1.02). When restricting to cohort studies, a borderline inverse relationship was found (OR = 0.93, 95% CI = 0.88-0.99). The adjusted and unadjusted OR were 0.92 (95% CI = 0.85-0.99) and 0.78 (95% CI = 0.73-0.84) for any vs. no yoghurt consumption and GC risk. The OR for 1 category of increase in yoghurt intake was 0.96 (95% CI = 0.91-1.02) for cardia, 1.03 (95% CI = 1.00-1.07) for non-cardia, 1.12 (95% CI = 1.07-1.19) for diffuse and 1.02 (95% CI = 0.97-1.06) for intestinal GC. No effect was seen within hospital-based and population-based studies, nor in men or women. Conclusions: We found no association between yoghurt and GC in the main adjusted models, despite sensitivity analyses suggesting a protective effect. Additional studies should further address this association.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13