Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Sousa, D (Autor) Outra; Lima, RT (Autor) Outra; Lopes Rodrigues, V (Autor) Outra; Gonzalez, E (Autor) Outra; Royo, F (Autor) Outra; Xavier, CPR (Autor) Outra; Falcon Perez, JM (Autor) Outra; Helena Vasconcelos, MH (Autor) FFUP

Revista

Título: Cells

Vol. 14

Página Final: 2886

ISSN: 2073-4409

Editora: MDPI

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00V-M9W

DOI: 10.3390/cells10112886

Abstract (EN): Cancer multidrug resistance (MDR) is one of the main challenges for cancer treatment efficacy. MDR is a phenomenon by which tumor cells become resistant to several unrelated drugs. Some studies have previously described the important role of extracellular vesicles (EVs) in the dissemination of a MDR phenotype. EVs' cargo may include different players of MDR, such as microRNAS and drug-efflux pumps, which may be transferred from donor MDR cells to recipient drug-sensitive counterparts. The present work aimed to: (i) compare the ability of drug-sensitive and their MDR counterpart cells to release and capture EVs and (ii) study and relate those differences with possible distinct fate of the endocytic pathway in these counterpart cells. Our results showed that MDR cells released more EVs than their drug-sensitive counterparts and also that the drug-sensitive cells captured more EVs than their MDR counterparts. This difference in the release and capture of EVs may be associated with differences in the endocytic pathway between drug-sensitive and MDR cells. Importantly, manipulation of the recycling pathway influenced the response of drug-sensitive cells to doxorubicin treatment.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 19