Emerging Target-Directed Approaches for the Treatment and Diagnosis of Microbial Infections

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Almeida, MC (Autor) Outra; da Costa, PM (Autor) Outra; Emilia Sousa (Autor) FFUP; Resende, DISP (Autor) Outra

Revista

Título: Journal of Medicinal Chemistry

Vol. 66

Páginas: 32-70

ISSN: 0022-2623

Editora: American Chemical Society

Indexação

ISI Web of Knowledge - 0 Citações

Scopus

Outras Informações

ID Authenticus: P-00X-Q4A

DOI: 10.1021/acs.jmedchem.2c01212

Abstract (EN): With the rising levels of drug resistance, developing efficient antimicrobial therapies has become a priority. A promising strategy is the conjugation of antibiotics with relevant moieties that can potentiate their activity by target-directing. The conjugation of siderophores with antibiotics allows them to act as Trojan horses by hijacking the microorganisms' highly developed iron transport systems and using them to carry the antibiotic into the cell. Through the analysis of relevant examples of the past decade, this Perspective aims to reveal the potential of siderophore-antibiotic Trojan horses for the treatment of infections and the role of siderophores in diagnostic techniques. Other conjugated molecules will be the subject of discussion, namely those involving vitamin B12, carbohydrates, and amino acids, as well as conjugated compounds targeting protein degradation and beta-lactamase activated prodrugs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 39