Apparent nosocomial adaptation of Enterococcus faecalis predates the modern hospital era

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Pöntinen, AK (Autor) Outra; Top, J (Autor) Outra; Arredondo Alonso, S (Autor) Outra; Tonkin Hill, G (Autor) Outra; Freitas, AR (Autor) Outra; Novais, Carla (Autor) FFUP; Gladstone, RA (Autor) Outra; Pesonen, M (Autor) Outra; Meneses, R (Autor) Outra; Pesonen, H (Autor) Outra; Lees, JA (Autor) Outra; Jamrozy, D (Autor) Outra; Bentley, SD (Autor) Outra; Lanza, VF (Autor) Outra; Torres, C (Autor) Outra; Luisa Peixe (Autor) FFUP; Coque, TM (Autor) Outra; Parkhill, J (Autor) Outra; Schürch, AC (Autor) Outra; Willems, RJL (Autor) Outra; Corander, J (Autor) Outra

Revista

Título: Nature Communications

Vol. 12

ISSN: 2041-1723

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 1 Citação

Outras Informações

ID Authenticus: P-00X-XWZ

DOI: 10.1038/s41467-021-21749-5

Abstract (EN): <jats:title>Abstract</jats:title><jats:p><jats:italic>Enterococcus faecalis</jats:italic> is a commensal and nosocomial pathogen, which is also ubiquitous in animals and insects, representing a classical generalist microorganism. Here, we study <jats:italic>E. faecalis</jats:italic> isolates ranging from the pre-antibiotic era in 1936 up to 2018, covering a large set of host species including wild birds, mammals, healthy humans, and hospitalised patients. We sequence the bacterial genomes using short- and long-read techniques, and identify multiple extant hospital-associated lineages, with last common ancestors dating back as far as the 19th century. We find a population cohesively connected through homologous recombination, a metabolic flexibility despite a small genome size, and a stable large core genome. Our findings indicate that the apparent hospital adaptations found in hospital-associated <jats:italic>E. faecalis</jats:italic> lineages likely predate the ¿modern hospital¿ era, suggesting selection in another niche, and underlining the generalist nature of this nosocomial pathogen.</jats:p>

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13