Dissolvable Carboxymethylcellulose Microneedles for Noninvasive and Rapid Administration of Diclofenac Sodium

• Tipo: Artigo em Revista Científica Internacional
• Data: 2022

Autores

Silva, ACQ (Autor) Outra; Pereira, B (Autor) Outra; Lameirinhas, NS (Autor) Outra; Paulo Costa (Autor) FFUP; Almeida, IF (Autor) Outra; Dias-Pereira, P (Autor) Outra; Correia-Sa, I (Autor) Outra; Oliveira, H (Autor) Outra; Silvestre, AJD (Autor) Outra; Vilela, C (Autor) Outra; Freire, CSR (Autor) Outra

Revista

Título: Macromolecular Bioscience

ISSN: 1616-5187

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 0 Citações

Scopus

Outras Informações

ID Authenticus: P-00X-DZS

DOI: 10.1002/mabi.202200323

Abstract (EN): The aim of this study is to prepare dissolvable biopolymeric microneedle (MN) patches composed solely of sodium carboxymethylcellulose (CMC), a water-soluble cellulose derivative with good film-forming ability, by micromolding technology for the transdermal delivery of diclofenac sodium salt (DCF). The MNs with approximate to 456 mu m in height displayed adequate morphology, thermal stability up to 200 degrees C, and the required mechanical strength for skin insertion (>0.15 N needle(-1)). Experiments in ex vivo abdominal human skin demonstrate the insertion capability of the CMC_DCF MNs up to 401 mu m in depth. The dissolution of the patches in saline buffer results in a maximum cumulative release of 98% of diclofenac after 40 min, and insertion in a skin simulant reveals that all MNs completely dissolve within 10 min. Moreover, the MN patches are noncytotoxic toward human keratinocytes. These results suggest that the MN patches produced with CMC are promising biopolymeric systems for the rapid administration of DCF in a minimally invasive manner.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11