Preparative separation of ketoprofen enantiomers: Choice of mobile phase composition and measurement of competitive adsorption isotherms

• Tipo: Artigo em Revista Científica Internacional
• Data: 2008

Autores

Ribeiro, AE (Autor) Outra; Graca, NS (Autor) Outra; Pais, LS (Autor) Outra; Alírio Rodrigues (Autor) FEUP

Revista

Título: Separation and Purification Technology

Vol. 61 Nº 3

Páginas: 375-383

ISSN: 1383-5866

Editora: Elsevier

Indexação

ISI Proceedings

ISI Web of Knowledge - 16 Citações

ISI Web of Science

Scopus - 16 Citações

COMPENDEX

Classificação Científica

FOS: Ciências da engenharia e tecnologias

CORDIS: Ciências Tecnológicas > Engenharia > Engenharia química

Outras Informações

ID Authenticus: P-003-XS3

DOI: 10.1016/j.seppur.2007.11.010

Abstract (EN): The present work intends to investigate how mobile phase composition influences the adsorption behavior of ketoprofen enantiomers (a nonsteroidal anti-inflainmatory drug) on an amylose-based chiral stationary phase (Chiralpak AD). Three mobile phase compositions were studied: the usual 20% ethanol/80% n-hexane mixture and two pure mobile phases; methanol and ethanol, Pulse and breakthrough experiments under preparative conditions were carried out in order to measure and test adsorption isotherms. The results obtained show that, for preparative separations, pure ethanol is a better mobile phase than the usual 20% ethanol/80% n-hexane mixture: it allows higher solubility of the racemate, lower retention times, and also a higher selectivity at high enantiomer concentrations. These are aspects of crucial importance when the final goal is to achieve high productivity preparative separations, as it is shown for the simulated moving bed (SMB) operation.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 9