The Role of Thyroid Hormones in Heart Failure

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Vale, C (Autor) Outra; Neves, JS (Autor) FMUP; von Hafe, M (Autor) Outra; Borges Canha, M (Autor) FMUP; Leite-Moreira AF (Autor) FMUP

Revista

Título: Cardiovascular Drugs and Therapy

Vol. 33

Páginas: 179-188

ISSN: 0920-3206

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 43 Citações

Scopus - 44 Citações

Outras Informações

ID Authenticus: P-00Q-B5E

DOI: 10.1007/s10557-019-06870-4

Abstract (EN): Cardiovascular diseases are the leading cause of death worldwide. Heart failure is the terminal manifestation of cardiovascular diseases, and its morbidity and mortality remain high. The prevalence of heart failure with preserved ejection fraction (HFpEF) among heart failure patients remains uncertain. However, recent studies have found that it ranged from 40 to 71%. There is still no effective treatment for HFpEF. Thyroid hormones (TH) have central regulatory actions in the cardiovascular system, particularly in the heart. Changes in plasmatic or tissue thyroid hormone levels are associated with significant alterations in cardiovascular function. A significant proportion of patients with heart failure presents some form of thyroid dysfunction including hypothyroidism, hyperthyroidism, and low T3 syndrome. Furthermore, thyroid hormones can vary at a local level independently of the serum TH levels. This may lead to local cardiac hypothyroidism in heart failure. Based on these findings and the role that TH play in cardiovascular regulation, they were proposed as a potential target for heart failure therapy. Several clinical and experimental studies have shown beneficial effects of TH supplementation. Data from epidemiological studies supports a higher risk of heart failure and a worse prognosis in heart failure patients with low levels of TH. In addition, animal studies and small clinical studies suggest that TH supplementation may improve cardiac function in heart failure. Although further studies are needed to evaluate the safety and efficacy of TH in this context, the available evidence suggests that TH modulation is a promising therapeutic approach to heart failure.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 10