Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity

• Tipo: Artigo em Revista Científica Internacional
• Data: 2005

Autores

Reis, JS (Autor) Outra; Simpson, PT (Autor) Outra; Jones, C (Autor) Outra; Steele, D (Autor) Outra; Mackay, A (Autor) Outra; Iravani, M (Autor) Outra; Fenwick, K (Autor) Outra; Valgeirsson, H (Autor) Outra; Lambros, M (Autor) Outra; Ashworth, A (Autor) Outra; Palacios, J (Autor) Outra; Fernando Schmitt (Autor) FMUP; Lakhani, SR (Autor) Outra

Revista

Título: Journal of Pathology

Vol. 207

Páginas: 1-13

ISSN: 0022-3417

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 148 Citações

Scopus - 173 Citações

Outras Informações

ID Authenticus: P-000-1N3

DOI: 10.1002/path.1806

Abstract (EN): Immunohistochemical analysis of E-cadherin has changed the way lobular neoplasia is perceived. It has helped to classify difficult cases of carcinoma in situ with indeterminate features and led to the identification of new variants of lobular carcinoma. Pleomorphic lobular carcinoma (PLC) and pleomorphic lobular carcinoma in situ (PLCIS), recently described variants of invasive and in situ classic lobular carcinoma, are reported to be associated with more aggressive clinical behaviour. Although PLC/PLCIS show morphological features of classic lobular neoplasia and lack E-cadherin expression, it is still unclear whether these lesions evolve through the same genetic pathway as lobular carcinomas or are high-grade ductal neoplasms that have lost E-cadherin. Here we have analysed a case of extensive PLCIS and invasive PLC associated with areas of E-cadherin-negative carcinoma in situ with indeterminate features, using immunohistochemistry, chromogenic in situ hybridization, high-resolution comparative genomic hybridization (CGH) and array-based CGH. We observed that all lesions lacked E-cadherin and beta-catenin and showed gain of 1q and loss of 16q, features that are typical of lobular carcinomas but are not seen in high-grade ductal lesions. In addition, amplifications of c-myc and HER2 were detected in the pleomorphic components, which may account for the high-grade features in this case and the reported aggressive clinical behaviour of these lesions. Taken together, these data suggest that at least some PLCs may evolve from the same precursor or through the same genetic pathway as classic lobular carcinomas. Copyright (c) 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13