Taking advantage of basic research: p63 is a reliable myoepithelial and stem cell marker

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2002

Autores

Reis, JS (Autor) Outra; Fernando Schmitt (Autor) FMUP

Revista

Título: Advances in Anatomic Pathology

Vol. 9

Páginas: 280-283

ISSN: 1072-4109

Editora: Wolters Kluwer Health

Indexação

ISI Web of Knowledge - 86 Citações

Outras Informações

ID Authenticus: P-000-N19

DOI: 10.1097/00125480-200209000-00002

Abstract (EN): p63 is a recently characterized p53-homolog that is consistently expressed by basal/somatic stem cells of stratified epithelia, myoepithelial cells of the breast and salivary glands, and proliferative compartment of gastric mucosa. p63 is located on the long arm of chromosome 3 (3q27) and it encodes six isoforms, three transactivating (TA) and three DeltaN-isoforms. While the first three isoforms may act as tumor suppressor genes, the DeltaN-isoforms may inhibit the p53/TA-p63-driven cell cycle arrest and apoptosis. Recently, the putative applications of p63 in the identification of myoepithelial cells of the breast and basal cells of the prostate acini have been evaluated however, no critical systematic analysis of its role in surgical pathology practice have hitherto been reported. We review the putative roles of p63 in surgical pathology practice and provide guidelines for future directions on p63 translational research.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 4