Selection of a new peptide homing SK-BR-3 breast cancer cells

• Tipo: Artigo em Revista Científica Internacional
• Data: 2021

Autores

Pereira, AC (Autor) Outra; Ferreira, D (Autor) Outra; Santos Pereira, C (Autor) Outra; Vieira, TF (Autor) Outra; Sergio Filipe Sousa (Autor) FCUP; Sales, G (Autor) Outra; Rodrigues, LR (Autor) Outra

Revista

Título: Chemical Biology and Drug Design

Vol. 97

Páginas: 893-903

ISSN: 1747-0277

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00T-7SX

DOI: 10.1111/cbdd.13816

Abstract (EN): Breast cancer diagnosis remains a challenge, mostly due to its heterogeneity. This reality translates in delayed treatments, increasing treatment aggressiveness and lower chances of overall survival. The conventional detection techniques, although becoming increasingly sophisticated each year, still lack the ability to provide reliable conclusions without being time consuming, expensive, and uncomfortable for the patients. The identification of novel biomarkers for breast cancer research is therefore of utmost relevance for an early diagnosis. Moreover, breast cancer-specific peptide moieties can be used to develop novel targeted drug delivery systems. In this work, we used phage display to identify a novel peptide with specificity to the SK-BR-3 breast cancer cell line. Cytometry assays confirmed its specificity, while bioinformatics and docking studies predicted the potential biomarkers at the SK-BR-3 cells' surface. These findings can be potentially useful in the clinical context, contributing to more specific and targeted therapeutic solutions against HER2-positive breast cancer subtypes.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 11