Epstein-Barr virus gene expression and latency pattern in gastric carcinomas: a systematic review

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2017

Autores

Ribeiro, J (Autor) Outra; Oliveira, C (Autor) ICBAS; Malta, M (Autor) Outra; Sousa, H (Autor) Outra

Revista

Título: Future Oncology

Vol. 13

Páginas: 567-579

ISSN: 1479-6694

Editora: Future Medicine Ltd.

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00M-F9Z

DOI: 10.2217/fon-2016-0475

Abstract (EN): Methods: A systematic review of literature was conducted to identify all published reports regarding the expression of Epstein-Barr Virus (EBV) proteins/transcripts and EBV latency patterns in EBV-associated gastric carcinomas (EBVaGC). Results: The literature search retrieved 247 papers, of which 25 papers matched the inclusion criteria. The analysis reveals that the most frequently expressed EBV latent proteins are EBNA1 (98.1%) and LMP2A (53.8%), while LMP1 and LMP2B are present in only 10% of cases. Lytic proteins, such as BARF0 and BARF1, and other lytic transcripts are present in almost half of cases. Conclusion: EBVaGC seems to display a unique transcription/latency pattern that does not fit the 'standard' EBV latency patterns and therefore should be further studied to better understand EBVaGC carcinogenesis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13