The Role of Extracellular Vesicles in the Hallmarks of Cancer and Drug Resistance

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2020

Autores

Xavier, CPR (Autor) Outra; Caires, HR (Autor) Outra; Barbosa, MAG (Autor) Outra; Bergantim, R (Autor) FMUP; Guimaraes, JE (Autor) Outra; Helena Vasconcelos, MH (Autor) FFUP

Revista

Título: Cells

Vol. 9

Página Final: 1141

ISSN: 2073-4409

Editora: MDPI

Indexação

ISI Web of Knowledge - 48 Citações

Scopus - 55 Citações

Outras Informações

ID Authenticus: P-00S-40Y

DOI: 10.3390/cells9051141

Abstract (EN): Extracellular vesicles (EVs) mediate intercellular signaling and communication, allowing the intercellular exchange of proteins, lipids, and genetic material. Their recognized role in the maintenance of the physiological balance and homeostasis seems to be severely disturbed throughout the carcinogenesis process. Indeed, the modus operandi of cancer implies the highjack of the EV signaling network to support tumor progression in many (if not all) human tumor malignancies. We have reviewed the current evidence for the role of EVs in affecting cancer hallmark traits by: (i) promoting cell proliferation and escape from apoptosis, (ii) sustaining angiogenesis, (iii) contributing to cancer cell invasion and metastasis, (iv) reprogramming energy metabolism, (v) transferring mutations, and (vi) modulating the tumor microenvironment (TME) by evading immune response and promoting inflammation. Special emphasis was given to the role of EVs in the transfer of drug resistant traits and to the EV cargo responsible for this transfer, both between cancer cells or between the microenvironment and tumor cells. Finally, we reviewed evidence for the increased release of EVs by drug resistant cells. A timely and comprehensive understanding of how tumor EVs facilitate tumor initiation, progression, metastasis and drug resistance is instrumental for the development of innovative EV-based therapeutic approaches for cancer.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 34