EGCG intestinal absorption and oral bioavailability enhancement using folic acid-functionalized nanostructured lipid carriers

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Granja, A (Autor) Outra; Neves, AR (Autor) Outra; Sousa, CT (Autor) FCUP; Pinheiro, M (Autor) Outra; Salette Reis (Autor) FFUP

Revista

Título: Heliyon

Vol. 5

ISSN: 2405-8440

Editora: Elsevier

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 23 Citações

Outras Informações

ID Authenticus: P-00Q-S42

DOI: 10.1016/j.heliyon.2019.e02020

Abstract (EN): This work aimed to develop folic acid-functionalized nanostructured lipid carriers (NLC) loading epigallocatechin-3- gallate (EGCG) to increase its oral bioavailability. An active targeting strategy was used and these nanoparticles (NPs) were fully characterized. The NP's effect on Caco-2 cell viability was evaluated and the apparent permeability (P-app) on a Caco-2 cell monolayer was determined. The results demonstrated that the developed NPs exhibited adequate physicochemical characteristics for oral administration and were found to be biocompatible with epithelial Caco-2 cells. Further, folic acid-functionalized EGCG-loaded NLC significantly increased EGCG transport across the intestinal barrier, promoting a 1.8- fold increase in its apparent permeability (P-app). Taken together, these results support that the developed NLC can be used as a promising carrier for safer and efficient management of several diseases since the pharmacokinetic (PK) properties of EGCG were improved with this nanomedicine-based strategy.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6