Hydrophilic Carbon Nanomaterials: Characterisation by Physical, Chemical, and Biological Assays

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Veloso, AD (Autor) Outra; Ferraria, AM (Autor) Outra; Botelho do Rego, AMB (Autor) Outra; Tavares, PB (Autor) Outra; Patricia Valentao (Autor) FFUP; David M Pereira (Autor) FFUP; Paula B Andrade (Autor) FFUP; Fernandes, AJ (Autor) Outra; Oliveira, MC (Autor) Outra; Videira, RA (Autor) Outra

Revista

Título: ChemMedChem

Vol. 14

Páginas: 699-711

ISSN: 1860-7179

Editora: Wiley-Blackwell

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 3 Citações

Outras Informações

ID Authenticus: P-00Q-9AZ

DOI: 10.1002/cmdc.201900003

Abstract (EN): A highly hydrophilic carbon nanomaterial was generated by using an electrochemical approach, and its structure, chemical composition, redox properties, antioxidant activity and effects on cells were characterised. It was found that the nanomaterial possesses a structure dominated by sp(2) carbon atoms in a non-ordered carbon network formed by small clusters (<2 nm) of a carbonaceous material. This material has an outstanding capability for donating electrons and an unusual ability to bind metal cations. Antioxidant activity assays showed that it displays a high scavenging activity against both 2,2-diphenyl-1-picrylhydrazyl and 2,2 '-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radicals, and a concentration-dependent ability to protect mitochondrial lipids and intracellular thiol groups from oxidation promoted by external oxidising agents. Cell-based assays also revealed that the nanomaterial has the ability to protect neuronal cells against oxidative damage and toxicity promoted by tert-butyl hydroperoxide and amyloid-beta(1-42) peptide. These results, combined with the attractive methodology for generating this hydrophilic carbon-based nanomaterial, make this study the first step in addressing the therapeutic application of this new material.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13