Structures, Activities and Drug-Likeness of Anti-Infective Xanthone Derivatives Isolated from the Marine Environment: A Review

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2019

Autores

Loureiro, DRP (Autor) Outra; Jose X Soares (Autor) FFUP; Costa, JC (Autor) Outra; Magalhaes, AF (Autor) Outra; Azevedo, CMG (Autor) Outra; Pinto, MMM (Autor) Outra; Carlos Afonso (Autor) FFUP

Revista

Título: Molecules

Vol. 24

Página Final: 243

ISSN: 1420-3049

Editora: MDPI

Indexação

ISI Web of Knowledge - 1 Citação

Scopus - 18 Citações

Outras Informações

ID Authenticus: P-00Q-2GC

DOI: 10.3390/molecules24020243

Abstract (EN): Marine organisms represent almost half of total biodiversity and are a very important source of new bioactive substances. Within the varied biological activities found in marine products, their antimicrobial activity is one of the most relevant. Infectious diseases are responsible for high levels of morbidity and mortality and many antimicrobials lose their effectiveness with time due to the development of resistance. These facts justify the high importance of finding new, effective and safe anti-infective agents. Among the variety of biological activities of marine xanthone derivatives, one that must be highlighted is their anti-infective properties. In this work, a literature review of marine xanthones with anti-infective activity, namely antibacterial, antifungal, antiparasitic and antiviral, is presented. Their structures, biological activity, sources and the methods used for bioactivity evaluation are described. The xanthone derivatives are grouped in three sets: xanthones, hydroxanthones and glycosylated derivatives. Moreover, molecular descriptors, biophysico-chemical properties, and pharmacokinetic parameters were calculated, and the chemical space occupied by marine xanthone derivatives is recognized. The chemical space was compared with marketed drugs and framed accordingly to the drug-likeness concept in order to profile the pharmacokinetic of anti-infective marine xanthone derivatives.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 23