Hepatotoxicity induced by paclitaxel interaction with turmeric in association with a microcystin from a contaminated dietary supplement

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Costa, ML (Autor) Outra; Rodrigues, JA (Autor) Outra; Azevedo, J (Autor) Outra; Vitor Vasconcelos (Autor) FCUP; Eiras, E (Autor) Outra; Campos, MG (Autor) Outra

Revista

Título: Toxicon

Vol. 150

Páginas: 207-211

ISSN: 0041-0101

Editora: Elsevier

Indexação

ISI Web of Knowledge - 22 Citações

Scopus - 26 Citações

Outras Informações

ID Authenticus: P-00P-G2P

DOI: 10.1016/j.toxicon.2018.05.022

Abstract (EN): A 67-year-old Caucasian male with lung cancer was presented to the Emergency Department with asthenia, anorexia, jaundice and choluria. The patient's lung cancer was being treated medically by a combination of paclitaxel/carboplatin with bi-monthly frequency. The patient was also self-medicating with several natural products, including Chlorella (520 mg/day), Silybum marianum (total of 13.5 mg silymarin/day), zinc sulphate (5.5 mg), selenium (50 mu g) and 15 g/day of Curcuma longa. In first chemotherapy cycle no toxicity was observed even he was taking other medications as budesonide and sitagliptin. The toxic events started only after the introduction of the dietary products. Chlorella had contamination with cyanobacteria (Oscillatoriales) and 1.08 mu g of cyanotoxin Microcystin-LR (MC-LR) per gram of biomass was found. Patient was consuming ca 0.01 mu g MC-LR/kg/day. This case report describes the first known case of paclitaxel toxicity probably related to pharmacokinetic interaction with Turmeric and a contaminated Chlorella supplement resulting in an acute toxic hepatitis and the impact on oncologic patient health.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 5