Solvatochromism as a new tool to distinguish structurally similar compounds

• Tipo: Artigo em Revista Científica Internacional
• Data: 2019

Autores

Pedro P. Madeira (Autor) Outra; Joana A. Loureiro (Autor) FEUP; Mara G. Freire (Autor) Outra; João A. P. Coutinho (Autor) Outra

Revista

Título: Journal of Molecular Liquids

Vol. 274

Páginas: 740-745

ISSN: 0167-7322

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 2 Citações

INSPEC

Outras Informações

ID Authenticus: P-00P-X20

DOI: 10.1016/j.molliq.2018.11.050

Abstract (EN): It is here reported a new concept based on solvatochromism to distinguish structurally similar compounds in aqueous solutions by the analysis of the stabilization of electronic excited states. The sensitivity of this approach to differentiate similar organic compounds, such as structural isomers or compound differing in the number of methylene groups, or proteins with conformational changes induced by being or not bound to cofactors, differing in two amino acids substitutions, or differing in their glycosylation profile, is demonstrated. The sensitivity of the proposed approach, based on the solvatochromic method, opens the path to its use as an auxiliary analytical tool in biomedical diagnosis/prognosis or in quality control of biologic-based drugs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6