A comprehensive review on xanthone derivatives as alpha-glucosidase inhibitors

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Santos, CMM (Autor) Outra; Freitas, M (Autor) Outra; Eduarda Fernandes (Autor) FFUP

Revista

Título: European Journal of Medicinal Chemistry

Vol. 157

Páginas: 1460-1479

ISSN: 0223-5234

Editora: Elsevier

Indexação

ISI Web of Knowledge - 6 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00P-KZK

DOI: 10.1016/j.ejmech.2018.07.073

Abstract (EN): alpha-Glucosidase plays an important role in carbohydrate metabolism and is therefore an attractive therapeutic target for the treatment of diabetes, obesity and other related complications. In the last two decades, considerable interest has been given to natural and synthetic xanthone derivatives in this field of research. Herein, a comprehensive review of the literature on xanthones as inhibitors of alpha-glucosidase activity, their mechanism of action, experimental procedures and structure-activity relationships have been reviewed for more than 280 analogs. With this overview we intend to motivate and challenge researchers (e.g. chemistry, biology, pharmaceutical and medicinal areas) for the design of novel xanthones as multipotent drugs and exploit the properties of this class of compounds in the management of diabetic complications.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 20