Involving the microRNA Targetome in Esophageal-Cancer Development and Behavior

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2018

Autores

Dias, F (Autor) Outra; Morais, M (Autor) Outra; Teixeira, AL (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: Cancers

Vol. 10

Página Final: 381

ISSN: 2072-6694

Editora: MDPI

Indexação

ISI Web of Knowledge - 9 Citações

Scopus - 9 Citações

Outras Informações

ID Authenticus: P-00P-TBS

DOI: 10.3390/cancers10100381

Abstract (EN): Esophageal cancer (EC) is the eighth most common and sixth leading cause of cancer-related mortality in the world. Despite breakthroughs in EC diagnosis and treatment, patients with complete pathologic response after being submitted to chemoradiotherapy are still submitted to surgery, despite its high morbidity. Single-nucleotide polymorphisms (SNPs) in miRNA, miRNA-binding sites, and in its biogenesis pathway genes can alter miRNA expression patterns, thereby influencing cancer risk and prognosis. In this review, we systematized the information available regarding the impact of these miR-SNPs in EC development and prognosis. We found 34 miR-SNPs that were associated with EC risk. Despite the promising applicability of these miR-SNPs as disease biomarkers, they still lack validation in non-Asian populations. Moreover, there should be more pathway-based approaches to evaluate the cumulative effect of multiple unfavorable genotypes and, consequently, identify miR-SNPs signatures capable of predicting EC therapy response and prognosis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 13